Endocrine Abstracts

Mammalian tissues are composed of heterogeneous populations of cells, interacting in highly structured microenvironments to achieve physiologic goals. Understanding the design principles of endocrine tissues organization requires approaches to analyze spatially-resolved sub-populations of cells within the tissue. The mammalian liver consists of hexagonal-shaped lobules, radially polarized by blood flow and morphogens. Key liver are differentially expressed along the lobule axi...